Thy-1 depletion and integrin β3 upregulation-mediated PI3K-Akt-mTOR pathway activation inhibits lung fibroblast autophagy in lipopolysaccharide-induced pulmonary fibrosis

Lipopolysaccharide (LPS)-induced autophagy inhibition in lung fibroblasts is closely associated with the activation of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K-Akt-mTOR) pathway. However, the underlying mechanism remains unknown. In this study, we demons...

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Detalles Bibliográficos
Autores principales: Wan, Hanxi, Xie, Tingting, Xu, Qiaoyi, Hu, Xiaoting, Xing, Shunpeng, Yang, Hao, Gao, Yuan, He, Zhengyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102294/
https://www.ncbi.nlm.nih.gov/pubmed/31249375
http://dx.doi.org/10.1038/s41374-019-0281-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102294/
https://www.ncbi.nlm.nih.gov/pubmed/31249375
http://dx.doi.org/10.1038/s41374-019-0281-2

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