Recent discovery and development of inhibitors targeting coronaviruses

Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded RNA genome. Currently, six human CoVs have been reported including human coronavirus 229E (HCoV-229E), OC43 (HCoV-OC43), NL63 (HCoV-NL63), HKU1 (HCoV-HKU1), severe acute respiratory syndrome (SARS) coronavirus (SA...

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Autores principales: Pillaiyar, Thanigaimalai, Meenakshisundaram, Sangeetha, Manickam, Manoj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102522/
https://www.ncbi.nlm.nih.gov/pubmed/32006468
http://dx.doi.org/10.1016/j.drudis.2020.01.015
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author Pillaiyar, Thanigaimalai
Meenakshisundaram, Sangeetha
Manickam, Manoj
author_facet Pillaiyar, Thanigaimalai
Meenakshisundaram, Sangeetha
Manickam, Manoj
author_sort Pillaiyar, Thanigaimalai
collection PubMed
description Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded RNA genome. Currently, six human CoVs have been reported including human coronavirus 229E (HCoV-229E), OC43 (HCoV-OC43), NL63 (HCoV-NL63), HKU1 (HCoV-HKU1), severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), and MiddleEast respiratory syndrome (MERS) coronavirus (MERS-CoV). They cause moderate to severe respiratory and intestinal infections in humans. In this review, we focus on recent advances in the research and development of small-molecule anti-human coronavirus therapies targeting different stages of the CoV life cycle.
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spelling pubmed-71025222020-03-31 Recent discovery and development of inhibitors targeting coronaviruses Pillaiyar, Thanigaimalai Meenakshisundaram, Sangeetha Manickam, Manoj Drug Discov Today Review Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded RNA genome. Currently, six human CoVs have been reported including human coronavirus 229E (HCoV-229E), OC43 (HCoV-OC43), NL63 (HCoV-NL63), HKU1 (HCoV-HKU1), severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), and MiddleEast respiratory syndrome (MERS) coronavirus (MERS-CoV). They cause moderate to severe respiratory and intestinal infections in humans. In this review, we focus on recent advances in the research and development of small-molecule anti-human coronavirus therapies targeting different stages of the CoV life cycle. Elsevier Ltd. 2020-04 2020-01-30 /pmc/articles/PMC7102522/ /pubmed/32006468 http://dx.doi.org/10.1016/j.drudis.2020.01.015 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Pillaiyar, Thanigaimalai
Meenakshisundaram, Sangeetha
Manickam, Manoj
Recent discovery and development of inhibitors targeting coronaviruses
title Recent discovery and development of inhibitors targeting coronaviruses
title_full Recent discovery and development of inhibitors targeting coronaviruses
title_fullStr Recent discovery and development of inhibitors targeting coronaviruses
title_full_unstemmed Recent discovery and development of inhibitors targeting coronaviruses
title_short Recent discovery and development of inhibitors targeting coronaviruses
title_sort recent discovery and development of inhibitors targeting coronaviruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102522/
https://www.ncbi.nlm.nih.gov/pubmed/32006468
http://dx.doi.org/10.1016/j.drudis.2020.01.015
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