SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health emergency. Cell entry of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors and on S protein priming by host...

Descripción completa

Detalles Bibliográficos
Autores principales: Hoffmann, Markus, Kleine-Weber, Hannah, Schroeder, Simon, Krüger, Nadine, Herrler, Tanja, Erichsen, Sandra, Schiergens, Tobias S., Herrler, Georg, Wu, Nai-Huei, Nitsche, Andreas, Müller, Marcel A., Drosten, Christian, Pöhlmann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102627/
https://www.ncbi.nlm.nih.gov/pubmed/32142651
http://dx.doi.org/10.1016/j.cell.2020.02.052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102627/
https://www.ncbi.nlm.nih.gov/pubmed/32142651
http://dx.doi.org/10.1016/j.cell.2020.02.052

Ejemplares similares