Cargando…

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health emergency. Cell entry of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors and on S protein priming by host...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoffmann, Markus, Kleine-Weber, Hannah, Schroeder, Simon, Krüger, Nadine, Herrler, Tanja, Erichsen, Sandra, Schiergens, Tobias S., Herrler, Georg, Wu, Nai-Huei, Nitsche, Andreas, Müller, Marcel A., Drosten, Christian, Pöhlmann, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102627/ https://www.ncbi.nlm.nih.gov/pubmed/32142651 http://dx.doi.org/10.1016/j.cell.2020.02.052

Ejemplares similares

The Hemagglutinin of Bat-Associated Influenza Viruses Is Activated by TMPRSS2 for pH-Dependent Entry into Bat but Not Human Cells
por: Hoffmann, Markus, et al.
Publicado: (2016)

Commentary: SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
por: Djomkam, Alexandra Lindsey Zune, et al.
Publicado: (2020)

Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2
por: Qiao, Yuanyuan, et al.
Publicado: (2021)

TMPRSS2: An Equally Important Protease as ACE2 in the Pathogenicity of SARS-CoV-2 Infection
por: Parmar, Malvinder S.
Publicado: (2021)

Expression Pattern of the SARS-CoV-2 Entry Genes ACE2 and TMPRSS2 in the Respiratory Tract
por: Liu, Yichuan, et al.
Publicado: (2020)

Expression of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in the Gut of Patients With IBD
por: Burgueño, Juan F, et al.
Publicado: (2020)

Evidence for an ACE2-Independent Entry Pathway That Can Protect from Neutralization by an Antibody Used for COVID-19 Therapy
por: Hoffmann, Markus, et al.
Publicado: (2022)

Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus
por: Kleine-Weber, Hannah, et al.
Publicado: (2020)

SARS-CoV-2 Targets by the pscRNA Profiling of ACE2, TMPRSS2 and Furin Proteases
por: Zhou, Lulin, et al.
Publicado: (2020)

Co-expression of the SARS-CoV-2 entry receptors ACE2 and TMPRSS2 in healthy human conjunctiva
por: Mencucci, Rita, et al.
Publicado: (2021)

SARS-CoV-2 entry inhibitors by dual targeting TMPRSS2 and ACE2: An in silico drug repurposing study
por: Baby, Krishnaprasad, et al.
Publicado: (2021)

Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin
por: Ouyang, Yingshi, et al.
Publicado: (2021)

Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challenges
por: Mahmoud, Ismail Sami, et al.
Publicado: (2021)

SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal–Fetal Interface
por: Chen, Wei, et al.
Publicado: (2020)

Variability in genes related to SARS-CoV-2 entry into host cells (ACE2, TMPRSS2, TMPRSS11A, ELANE, and CTSL) and its potential use in association studies
por: Vargas-Alarcón, Gilberto, et al.
Publicado: (2020)

Cholesterol Dependence of Pseudorabies Herpesvirus Entry
por: Ren, Xiaofeng, et al.
Publicado: (2010)

Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester
por: Weatherbee, Bailey A. T., et al.
Publicado: (2020)

Role of Vitamin D, ACE2 and the Proteases as TMPRSS2 and Furin on SARS-CoV-2 Pathogenesis and COVID-19 Severity
por: Ortatatli, Mesut, et al.
Publicado: (2023)

Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat
por: Hempel, Tim, et al.
Publicado: (2020)

Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury
por: Bengs, Susan, et al.
Publicado: (2021)

Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2
por: Baratchian, Mehdi, et al.
Publicado: (2020)

Soluble ACE2 and TMPRSS2 Levels in the Serum of Asthmatic Patients
por: Lee, Ji-Hyang, et al.
Publicado: (2022)

ACE inhibitors on ACE1, ACE2, and TMPRSS2 expression and spheroid attachment on human endometrial Ishikawa cells
por: Fernando, Sudini R., et al.
Publicado: (2022)

Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L
por: Prasad, Kartikay, et al.
Publicado: (2021)

Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes
por: Robinson, Emma L., et al.
Publicado: (2020)

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells
por: Coate, Katie C., et al.
Publicado: (2020)

Computational Analysis of Targeting SARS-CoV-2, Viral Entry Proteins ACE2 and TMPRSS2, and Interferon Genes by Host MicroRNAs
por: Pierce, Jacob B., et al.
Publicado: (2020)

Co-expression of the SARS-CoV-2 entry molecules ACE2 and TMPRSS2 in human ovaries: Identification of cell types and trends with age
por: Wu, Meng, et al.
Publicado: (2021)

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity
por: Hoffmann, Markus, et al.
Publicado: (2020)

Fusogenicity of the Ghana Virus (Henipavirus: Ghanaian bat henipavirus) Fusion Protein is Controlled by the Cytoplasmic Domain of the Attachment Glycoprotein
por: Voigt, Kathleen, et al.
Publicado: (2019)

ACE2 and TMPRSS2 Expression in Hepatocytes of Chronic HBV Infection Patients
por: Hu, Xiao-Xiao, et al.
Publicado: (2021)

Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19
por: Shafiee, Sepehr, et al.
Publicado: (2021)

ACE2 and TMPRSS2 Immunolocalization and COVID-19-Related Thyroid Disorder
por: Park, Gi-Cheol, et al.
Publicado: (2022)

GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies
por: Wu, Ching-Yuan, et al.
Publicado: (2020)

Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells
por: Kimura, Hiroki, et al.
Publicado: (2020)

Structural modeling and analysis of the SARS-CoV-2 cell entry inhibitor camostat bound to the trypsin-like protease TMPRSS2
por: Escalante, Diego E., et al.
Publicado: (2021)

Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19
por: Ren, Xiaohan, et al.
Publicado: (2020)

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity
por: Hoffmann, Markus, et al.
Publicado: (2021)

Analysis of Ebola Virus Entry Into Macrophages
por: Dahlmann, Franziska, et al.
Publicado: (2015)

The Transmembrane Protease Serine 2 (TMPRSS2) Non-Protease Domains Regulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike-Mediated Virus Entry
por: Strobelt, Romano, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qihiirfp7an3i1d70jh0f4j3mo