Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication

Replication of coronaviruses is inhibited in vitro by cyclosporin A, a well-known immunosuppressive drug which binds to cellular cyclophilins thus inactivating their enzymatic cis-trans peptidyl-prolyl isomerase function. Latter is required for proper folding of cellular proteins and of proteins of...

Descripción completa

Detalles Bibliográficos
Autores principales: von Brunn, Albrecht, Ciesek, Sandra, von Brunn, Brigitte, Carbajo-Lozoya, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102849/
https://www.ncbi.nlm.nih.gov/pubmed/26318518
http://dx.doi.org/10.1016/j.coviro.2015.08.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102849/
https://www.ncbi.nlm.nih.gov/pubmed/26318518
http://dx.doi.org/10.1016/j.coviro.2015.08.004

Ejemplares similares