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Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication

Replication of coronaviruses is inhibited in vitro by cyclosporin A, a well-known immunosuppressive drug which binds to cellular cyclophilins thus inactivating their enzymatic cis-trans peptidyl-prolyl isomerase function. Latter is required for proper folding of cellular proteins and of proteins of...

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Detalles Bibliográficos
Autores principales:	von Brunn, Albrecht, Ciesek, Sandra, von Brunn, Brigitte, Carbajo-Lozoya, Javier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102849/ https://www.ncbi.nlm.nih.gov/pubmed/26318518 http://dx.doi.org/10.1016/j.coviro.2015.08.004

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