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Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells
Mutations in the LMNA gene, which encodes the nuclear envelope (NE) proteins lamins A/C, cause Emery-Dreifuss muscular dystrophy, congenital muscular dystrophy, and other diseases collectively known as laminopathies. The mechanisms responsible for these diseases remain incompletely understood. Using...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102937/ https://www.ncbi.nlm.nih.gov/pubmed/31844279 http://dx.doi.org/10.1038/s41563-019-0563-5 |