Effects of chain length and geometry on the activation of DNA damage bypass by polyubiquitylated PCNA

Ubiquitylation of the eukaryotic sliding clamp, PCNA, activates a pathway of DNA damage bypass that facilitates the replication of damaged DNA. In its monoubiquitylated form, PCNA recruits a set of damage-tolerant DNA polymerases for translesion synthesis. Alternatively, modification by K63-linked p...

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Detalles Bibliográficos
Autores principales: Takahashi, Diane T, Wollscheid, Hans-Peter, Lowther, Jonathan, Ulrich, Helle D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102961/
https://www.ncbi.nlm.nih.gov/pubmed/32009145
http://dx.doi.org/10.1093/nar/gkaa053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102961/
https://www.ncbi.nlm.nih.gov/pubmed/32009145
http://dx.doi.org/10.1093/nar/gkaa053

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