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Effects of chain length and geometry on the activation of DNA damage bypass by polyubiquitylated PCNA

Ubiquitylation of the eukaryotic sliding clamp, PCNA, activates a pathway of DNA damage bypass that facilitates the replication of damaged DNA. In its monoubiquitylated form, PCNA recruits a set of damage-tolerant DNA polymerases for translesion synthesis. Alternatively, modification by K63-linked p...

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Detalles Bibliográficos
Autores principales:	Takahashi, Diane T, Wollscheid, Hans-Peter, Lowther, Jonathan, Ulrich, Helle D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102961/ https://www.ncbi.nlm.nih.gov/pubmed/32009145 http://dx.doi.org/10.1093/nar/gkaa053

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