Dynamic structural insights into the molecular mechanism of DNA unwinding by the bacteriophage T7 helicase

The hexametric T7 helicase (gp4) adopts a spiral lock-washer form and encircles a coil-like DNA (tracking) strand with two nucleotides bound to each subunit. However, the chemo-mechanical coupling mechanism in unwinding has yet to be elucidated. Here, we utilized nanotensioner-enhanced Förster reson...

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Detalles Bibliográficos
Autores principales: Ma, Jian-Bing, Chen, Ze, Xu, Chun-Hua, Huang, Xing-Yuan, Jia, Qi, Zou, Zhen-Yu, Mi, Chen-Yang, Ma, Dong-Fei, Lu, Ying, Zhang, Hui-Dong, Li, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102974/
https://www.ncbi.nlm.nih.gov/pubmed/32009150
http://dx.doi.org/10.1093/nar/gkaa057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102974/
https://www.ncbi.nlm.nih.gov/pubmed/32009150
http://dx.doi.org/10.1093/nar/gkaa057

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