Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins

The S phase checkpoint is crucial to maintain genome stability under conditions that threaten DNA replication. One of its critical functions is to prevent Exo1-dependent fork degradation, and Exo1 is phosphorylated in response to different genotoxic agents. Exo1 seemed to be regulated by several pos...

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Detalles Bibliográficos
Autores principales: Morafraile, Esther C, Bugallo, Alberto, Carreira, Raquel, Fernández, María, Martín-Castellanos, Cristina, Blanco, Miguel G, Segurado, Mónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102976/
https://www.ncbi.nlm.nih.gov/pubmed/32020204
http://dx.doi.org/10.1093/nar/gkaa054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102976/
https://www.ncbi.nlm.nih.gov/pubmed/32020204
http://dx.doi.org/10.1093/nar/gkaa054

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