Cargando…

Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins

The S phase checkpoint is crucial to maintain genome stability under conditions that threaten DNA replication. One of its critical functions is to prevent Exo1-dependent fork degradation, and Exo1 is phosphorylated in response to different genotoxic agents. Exo1 seemed to be regulated by several pos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morafraile, Esther C, Bugallo, Alberto, Carreira, Raquel, Fernández, María, Martín-Castellanos, Cristina, Blanco, Miguel G, Segurado, Mónica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102976/ https://www.ncbi.nlm.nih.gov/pubmed/32020204 http://dx.doi.org/10.1093/nar/gkaa054

Ejemplares similares

Symmetric activity of DNA polymerases at and recruitment of exonuclease ExoR and of PolA to the Bacillus subtilis replication forks
por: Hernández-Tamayo, Rogelio, et al.
Publicado: (2019)

Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability
por: Colosio, Arianna, et al.
Publicado: (2016)

Cooperation of RAD51 and RAD54 in regression of a model replication fork
por: Bugreev, Dmitry V., et al.
Publicado: (2011)

Metnase promotes restart and repair of stalled and collapsed replication forks
por: De Haro, Leyma P., et al.
Publicado: (2010)

The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation
por: Iannascoli, Chiara, et al.
Publicado: (2015)

RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases
por: Guh, Chia-Lun, et al.
Publicado: (2023)

RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease
por: Aiello, Francesca Antonella, et al.
Publicado: (2019)

Replication fork collapse is a major cause of the high mutation frequency at three-base lesion clusters
por: Sedletska, Yuliya, et al.
Publicado: (2013)

Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart
por: Somyajit, Kumar, et al.
Publicado: (2015)

A novel single-stranded DNA-specific 3′–5′ exonuclease, Thermus thermophilus exonuclease I, is involved in several DNA repair pathways
por: Shimada, Atsuhiro, et al.
Publicado: (2010)

Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cells
por: Kaushik Tiwari, Meetu, et al.
Publicado: (2016)

Rad5 dysregulation drives hyperactive recombination at replication forks resulting in cisplatin sensitivity and genome instability
por: Bryant, Eric E, et al.
Publicado: (2019)

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
por: Bolderson, Emma, et al.
Publicado: (2010)

A role for 3′ exonucleases at the final stages of chromosome duplication in Escherichia coli
por: Midgley-Smith, Sarah L, et al.
Publicado: (2019)

The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart
por: Zhang, Qianting, et al.
Publicado: (2023)

A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks
por: Durando, Michael, et al.
Publicado: (2013)

ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1
por: Kijas, Amanda W., et al.
Publicado: (2015)

Motif WFYY of human PrimPol is crucial to stabilize the incoming 3′-nucleotide during replication fork restart
por: Calvo, Patricia A, et al.
Publicado: (2021)

FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability
por: Liu, Wenpeng, et al.
Publicado: (2023)

Rad53 regulates the lifetime of Rdh54 at homologous recombination intermediates
por: Hu, Jingyi, et al.
Publicado: (2023)

Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription
por: Brambati, Alessandra, et al.
Publicado: (2018)

Editing of misaligned 3′-termini by an intrinsic 3′–5′ exonuclease activity residing in the PHP domain of a family X DNA polymerase
por: Baños, Benito, et al.
Publicado: (2008)

Role of PCNA-dependent stimulation of 3′-phosphodiesterase and 3′–5′ exonuclease activities of human Ape2 in repair of oxidative DNA damage
por: Burkovics, Peter, et al.
Publicado: (2009)

Switching between polymerase and exonuclease sites in DNA polymerase ε
por: Ganai, Rais A., et al.
Publicado: (2015)

PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates
por: Mathavarajah, Sabateeshan, et al.
Publicado: (2023)

Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells
por: Batenburg, Nicole L, et al.
Publicado: (2021)

Mechanism of Exonuclease I stimulation by the single-stranded DNA-binding protein
por: Lu, Duo, et al.
Publicado: (2011)

Dissecting endonuclease and exonuclease activities in endonuclease V from Thermotoga maritima
por: Mi, Rongjuan, et al.
Publicado: (2011)

Stability of blocked replication forks in vivo
por: Mettrick, Karla A., et al.
Publicado: (2016)

Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A–RAD18 ternary complex
por: Masuda, Yuji, et al.
Publicado: (2012)

Human RAD51 paralogue RAD51C fosters repair of alkylated DNA by interacting with the ALKBH3 demethylase
por: Mohan, Monisha, et al.
Publicado: (2019)

Hydrolytic function of Exo1 in mammalian mismatch repair
por: Shao, Hongbing, et al.
Publicado: (2014)

RecJ-like protein from Pyrococcus furiosus has 3′–5′ exonuclease activity on RNA: implications for proofreading of 3′-mismatched RNA primers in DNA replication
por: Yuan, Hui, et al.
Publicado: (2013)

Coordination of Rad1–Rad10 interactions with Msh2–Msh3, Saw1 and RPA is essential for functional 3′ non-homologous tail removal
por: Eichmiller, Robin, et al.
Publicado: (2018)

The RNA binding protein Npl3 promotes resection of DNA double-strand breaks by regulating the levels of Exo1
por: Colombo, Chiara Vittoria, et al.
Publicado: (2017)

Involvement of Exo1b in DNA damage-induced apoptosis
por: Bolderson, Emma, et al.
Publicado: (2009)

PCNA promotes processive DNA end resection by Exo1
por: Chen, Xiaoqing, et al.
Publicado: (2013)

End-processing during non-homologous end-joining: a role for exonuclease 1
por: Bahmed, Karim, et al.
Publicado: (2011)

The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55–Rad57 to mediate error-free recombination
por: Godin, Stephen, et al.
Publicado: (2013)

Characterization of the SARS-CoV-2 ExoN (nsp14(ExoN)–nsp10) complex: implications for its role in viral genome stability and inhibitor identification
por: Baddock, Hannah T, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1co6v2p8uq1fffs2hcac629vr1