Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8

[Image: see text] Misregulation of Wnt signaling is common in human cancer. The development of small molecule inhibitors against the Wnt receptor, frizzled (FZD), may have potential in cancer therapy. During small molecule screens, we observed binding of carbamazepine to the cysteine-rich domain (CR...

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Detalles Bibliográficos
Autores principales: Zhao, Yuguang, Ren, Jingshan, Hillier, James, Lu, Weixian, Jones, E. Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104226/
https://www.ncbi.nlm.nih.gov/pubmed/32049522
http://dx.doi.org/10.1021/acs.jmedchem.9b02020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104226/
https://www.ncbi.nlm.nih.gov/pubmed/32049522
http://dx.doi.org/10.1021/acs.jmedchem.9b02020

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