Cargando…

Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8

[Image: see text] Misregulation of Wnt signaling is common in human cancer. The development of small molecule inhibitors against the Wnt receptor, frizzled (FZD), may have potential in cancer therapy. During small molecule screens, we observed binding of carbamazepine to the cysteine-rich domain (CR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Yuguang, Ren, Jingshan, Hillier, James, Lu, Weixian, Jones, E. Yvonne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104226/ https://www.ncbi.nlm.nih.gov/pubmed/32049522 http://dx.doi.org/10.1021/acs.jmedchem.9b02020

Ejemplares similares

Caffeine inhibits Notum activity by binding at the catalytic pocket
por: Zhao, Yuguang, et al.
Publicado: (2020)

Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum
por: Zhao, Yuguang, et al.
Publicado: (2020)

Drug interaction between carbamazepine and other antiepileptic drugs in Tunisian epileptic patients
por: Gaies, Emna, et al.
Publicado: (2021)

Neuropsychological effects of antiepileptic drugs (carbamazepine versus valproate) in adult males with epilepsy
por: Shehata, Ghaydaa A, et al.
Publicado: (2009)

Inhibition of Wnt/β-Catenin Signaling by a Soluble Collagen-Derived Frizzled Domain Interacting with Wnt3a and the Receptors Frizzled 1 and 8
por: Hendaoui, Ismaïl, et al.
Publicado: (2012)

Correction: Inhibition of Wnt/β-Catenin Signaling by a Soluble Collagen-Derived Frizzled Domain Interacting with Wnt3a and the Receptors Frizzled 1 and 8
por: Hendaoui, Ismaïl, et al.
Publicado: (2012)

Prevalence of Side Effects Treatment with Carbamazepine and Other Antiepileptics in Patients with Epilepsy
por: Koliqi, Rozafa, et al.
Publicado: (2015)

Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer
por: Bravo, Dawn T, et al.
Publicado: (2013)

Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function
por: Varela-Nallar, Lorena, et al.
Publicado: (2009)

The Levels of Wnt5a and Its Receptors Frizzled5 and Frizzled2 as Immunohistochemical Biomarkers of Severity of Psoriasis
por: Ning, Xiaoying, et al.
Publicado: (2021)

Wnt Binding Affinity Prediction for Putative Frizzled-Type Cysteine-Rich Domains
por: Agostino, Mark, et al.
Publicado: (2019)

Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma
por: Bengochea, A, et al.
Publicado: (2008)

The hairpin region of WNT7A is sufficient for binding to the Frizzled7 receptor and to elicit signaling in myogenic cells
por: Schmidt, Manuel, et al.
Publicado: (2022)

Beverage-induced enhanced bioavailability of carbamazepine and its consequent effect on antiepileptic activity and toxicity
por: Karmakar, Sanmoy, et al.
Publicado: (2014)

Comparison of myocardial perfusion between the users of two antiepileptic medications: valproate vs. carbamazepine
por: Peymani, Zeinab, et al.
Publicado: (2023)

Comment on: “Wnt Binding Affinity Prediction for Putative Frizzled-Type Cysteine-Rich Domains”
por: Musso, Orlando
Publicado: (2019)

Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells
por: Planutis, Kestutis, et al.
Publicado: (2007)

Expression of the Wnt Receptor Frizzled-4 in the Human Enteric Nervous System of Infants
por: Nothelfer, Katharina, et al.
Publicado: (2016)

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families
por: Voloshanenko, Oksana, et al.
Publicado: (2017)

Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity
por: Kumar, Sumit, et al.
Publicado: (2014)

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer
por: Murillo-Garzón, Virginia, et al.
Publicado: (2018)

Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8
por: Kim, Hyun-Taek, et al.
Publicado: (2017)

Antiepileptic drug carbamazepine promotes horizontal transfer of plasmid-borne multi-antibiotic resistance genes within and across bacterial genera
por: Wang, Yue, et al.
Publicado: (2018)

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan
por: Chang, Tao-Hsin, et al.
Publicado: (2015)

The Wnt Serpentine Receptor Frizzled-9 Regulates New Bone Formation in Fracture Healing
por: Heilmann, Aline, et al.
Publicado: (2013)

Glutathione facilitates enterovirus assembly by binding at a druggable pocket
por: Duyvesteyn, Helen M. E., et al.
Publicado: (2020)

Functional role of the Frizzled linker domain in the Wnt signaling pathway
por: Ko, Seung-Bum, et al.
Publicado: (2022)

Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation
por: Teo, Samuel, et al.
Publicado: (2021)

eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled
por: Wesslowski, Janine, et al.
Publicado: (2020)

Antiepileptic Drugs
por: Prichard, J. W.
Publicado: (1974)

Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5(+) Stem Cells
por: Flanagan, Dustin J., et al.
Publicado: (2015)

Frizzled7: A Promising Achilles’ Heel for Targeting the Wnt Receptor Complex to Treat Cancer
por: Phesse, Toby, et al.
Publicado: (2016)

Angled Growth of the Dental Lamina Is Accompanied by Asymmetrical Expression of the WNT Pathway Receptor Frizzled 6
por: Putnová, Iveta, et al.
Publicado: (2017)

Wnt Receptor Frizzled-4 as a Marker for Isolation of Enteric Neural Progenitors in Human Children
por: Neckel, Peter H., et al.
Publicado: (2019)

Quantitative Pharmaco-Electroencephalography in Antiepileptic Drug Research
por: Höller, Yvonne, et al.
Publicado: (2018)

Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters
por: Palomer, Ernest, et al.
Publicado: (2022)

Frizzled-Dependent Planar Cell Polarity without Secreted Wnt Ligands
por: Yu, Joyce J.S., et al.
Publicado: (2020)

Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin
por: Wei, Wei, et al.
Publicado: (2011)

A secreted splice variant of the Xenopus frizzled-4 receptor is a biphasic modulator of Wnt signalling
por: Gorny, Anne-Kathrin, et al.
Publicado: (2013)

Wnt Signaling Mediates LTP-Dependent Spine Plasticity and AMPAR Localization through Frizzled-7 Receptors
por: McLeod, Faye, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_qfpv3ncuoajvrabt9dfs2t5v41