Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

[Image: see text] A major resistance mechanism in Gram-negative bacteria is the production of β-lactamase enzymes. Originally recognized for their ability to hydrolyze penicillins, emergent β-lactamases can now confer resistance to other β-lactam drugs, including both cephalosporins and carbapenems....

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Bin, Trout, Robert E. Lee, Chu, Guo-Hua, McGarry, Daniel, Jackson, Randy W., Hamrick, Jodie C., Daigle, Denis M., Cusick, Susan M., Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Docquier, Jean-Denis, Weiss, William J., Pevear, Daniel C., Xerri, Luigi, Burns, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104248/
https://www.ncbi.nlm.nih.gov/pubmed/31765155
http://dx.doi.org/10.1021/acs.jmedchem.9b01518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104248/
https://www.ncbi.nlm.nih.gov/pubmed/31765155
http://dx.doi.org/10.1021/acs.jmedchem.9b01518

Ejemplares similares