Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease

CLN6-Batten disease is a rare neurodegenerative disorder with no cure, characterized by accumulation of lipofuscin in the lysosome, glial activation, and neuronal death. Here we test the therapeutic efficacy of modulating collapsin response mediator protein 2 (CRMP2) activity via S-N-benzy-2-acetami...

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Detalles Bibliográficos
Autores principales: White, Katherine A., Cain, Jacob T., Magee, Helen, Yeon, Seul Ki, Park, Ki Duk, Khanna, Rajesh, Weimer, Jill M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Translational Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104323/
https://www.ncbi.nlm.nih.gov/pubmed/32269836
http://dx.doi.org/10.1042/NS20190001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104323/
https://www.ncbi.nlm.nih.gov/pubmed/32269836
http://dx.doi.org/10.1042/NS20190001

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