Structural Basis of Cycloaddition in Biosynthesis of Iboga and Aspidosperma Alkaloids

Cycloaddition reactions generate chemical complexity in a single step. Here we report the crystal structures of three homologous plant-derived cyclases involved in the biosynthesis of iboga and aspidosperma alkaloids. These enzymes act on the same substrate, named angryline, to generate three distin...

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Detalles Bibliográficos
Autores principales: Caputi, Lorenzo, Franke, Jakob, Bussey, Kate, Farrow, Scott C., Vieira, Ivo Jose Curcino, Stevenson, Clare E. M., Lawson, David M., O’Connor, Sarah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104359/
https://www.ncbi.nlm.nih.gov/pubmed/32066966
http://dx.doi.org/10.1038/s41589-019-0460-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104359/
https://www.ncbi.nlm.nih.gov/pubmed/32066966
http://dx.doi.org/10.1038/s41589-019-0460-x

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