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Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM

Increasing evidence suggests that amyloid polymorphism gives rise to different strains of amyloids with distinct toxicities and pathology-spreading properties. Validating this hypothesis is challenging due to a lack of tools and methods that allow for the direct characterization of amyloid polymorph...

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Detalles Bibliográficos
Autores principales: Cendrowska, Urszula, Silva, Paulo Jacob, Ait-Bouziad, Nadine, Müller, Marie, Guven, Zekiye Pelin, Vieweg, Sophie, Chiki, Anass, Radamaker, Lynn, Kumar, Senthil T., Fändrich, Marcus, Tavanti, Francesco, Menziani, Maria Cristina, Alexander-Katz, Alfredo, Stellacci, Francesco, Lashuel, Hilal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104366/
https://www.ncbi.nlm.nih.gov/pubmed/32161130
http://dx.doi.org/10.1073/pnas.1916176117