Structural basis for RNA polymerase III transcription repression by Maf1

Maf1 is a conserved inhibitor of RNA polymerase III (Pol III) that influences phenotypes from metabolic efficiency to lifespan. Here, we present a 3.3 Å cryo-EM structure of yeast Maf1 bound to Pol III, establishing that Maf1 sequesters Pol III elements involved in transcription initiation and binds...

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Detalles Bibliográficos
Autores principales: Vorländer, Matthias K., Baudin, Florence, Moir, Robyn D., Wetzel, René, Hagen, Wim J. H., Willis, Ian M., Müller, Christoph W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104376/
https://www.ncbi.nlm.nih.gov/pubmed/32066962
http://dx.doi.org/10.1038/s41594-020-0383-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104376/
https://www.ncbi.nlm.nih.gov/pubmed/32066962
http://dx.doi.org/10.1038/s41594-020-0383-y

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