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Structural basis for RNA polymerase III transcription repression by Maf1
Maf1 is a conserved inhibitor of RNA polymerase III (Pol III) that influences phenotypes from metabolic efficiency to lifespan. Here, we present a 3.3 Å cryo-EM structure of yeast Maf1 bound to Pol III, establishing that Maf1 sequesters Pol III elements involved in transcription initiation and binds...
Autores principales: | Vorländer, Matthias K., Baudin, Florence, Moir, Robyn D., Wetzel, René, Hagen, Wim J. H., Willis, Ian M., Müller, Christoph W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104376/ https://www.ncbi.nlm.nih.gov/pubmed/32066962 http://dx.doi.org/10.1038/s41594-020-0383-y |
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