Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain

Chronic inflammation during Alzheimer’s disease (AD) is most often attributed to sustained microglial activation in response to amyloid-β (Aβ) plaque deposits and cell death. However, cytokine release and microgliosis are consistently observed in AD transgenic animal models devoid of such pathologie...

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Detalles Bibliográficos
Autores principales: Welikovitch, Lindsay A., Do Carmo, Sonia, Maglóczky, Zsófia, Malcolm, Janice C., Lőke, János, Klein, William L., Freund, Tamás, Cuello, A. Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104377/
https://www.ncbi.nlm.nih.gov/pubmed/32144141
http://dx.doi.org/10.1073/pnas.1914593117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104377/
https://www.ncbi.nlm.nih.gov/pubmed/32144141
http://dx.doi.org/10.1073/pnas.1914593117

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