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Effects of cell phenotype and seeding density on the chondrogenic capacity of human osteoarthritic chondrocytes in type I collagen scaffolds

OBJECTIVE: Matrix-associated autologous chondrocyte implantation (MACI) achieves good clinical efficacy in young patients with focal cartilage injury; however, phenotypic de-differentiation of chondrocytes cultured in monolayer and the treatment of older OA patients are still challenges in the field...

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Detalles Bibliográficos
Autores principales: Cao, Chenxi, Zhang, Yujun, Ye, Yanqi, Sun, Tiezheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104498/
https://www.ncbi.nlm.nih.gov/pubmed/32228637
http://dx.doi.org/10.1186/s13018-020-01617-6