Unusually persistent Gα(i)-signaling of the neuropeptide Y(2) receptor depletes cellular G(i/o) pools and leads to a G(i)-refractory state

BACKGROUND: A sensitive balance between receptor activation and desensitization is crucial for cellular homeostasis. Like many other GPCR, the human neuropeptide Y(2) receptor (hY(2)R) undergoes ligand dependent activation and internalization into intracellular compartments, followed by recycling to...

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Detalles Bibliográficos
Autores principales: Ziffert, Isabelle, Kaiser, Anette, Babilon, Stefanie, Mörl, Karin, Beck-Sickinger, Annette G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104545/
https://www.ncbi.nlm.nih.gov/pubmed/32223755
http://dx.doi.org/10.1186/s12964-020-00537-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104545/
https://www.ncbi.nlm.nih.gov/pubmed/32223755
http://dx.doi.org/10.1186/s12964-020-00537-6

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