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Unusually persistent Gα(i)-signaling of the neuropeptide Y(2) receptor depletes cellular G(i/o) pools and leads to a G(i)-refractory state
BACKGROUND: A sensitive balance between receptor activation and desensitization is crucial for cellular homeostasis. Like many other GPCR, the human neuropeptide Y(2) receptor (hY(2)R) undergoes ligand dependent activation and internalization into intracellular compartments, followed by recycling to...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104545/ https://www.ncbi.nlm.nih.gov/pubmed/32223755 http://dx.doi.org/10.1186/s12964-020-00537-6 |