Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation

Although ATRA represents a successful differentiation therapy for APL, it is largely ineffective for non-APL AMLs. Hence combination therapies using an agent targeting ATRA-regulated molecules that drive cell differentiation/arrest are of interest. Using the HL-60 human non-APL AML model where ATRA...

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Detalles Bibliográficos
Autores principales: Rashid, Asif, Duan, Xin, Gao, Feng, Yang, Mengsu, Yen, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105165/
https://www.ncbi.nlm.nih.gov/pubmed/32256976
http://dx.doi.org/10.18632/oncotarget.27508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105165/
https://www.ncbi.nlm.nih.gov/pubmed/32256976
http://dx.doi.org/10.18632/oncotarget.27508

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