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Co-evolution within structured bacterial communities results in multiple expansion of CRISPR loci and enhanced immunity

Type II CRISPR-Cas systems provide immunity against phages and plasmids that infect bacteria through the insertion of a short sequence from the invader’s genome, known as the ‘spacer’, into the CRISPR locus. Spacers are transcribed into guide RNAs that direct the Cas9 nuclease to its target on the i...

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Detalles Bibliográficos
Autores principales: Pyenson, Nora C, Marraffini, Luciano A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105378/
https://www.ncbi.nlm.nih.gov/pubmed/32223887
http://dx.doi.org/10.7554/eLife.53078