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Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios
The distribution of fitness effects (DFE) defines how new mutations spread through an evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method to detect selection in somatic cells. However the link, in somatic evolution, between dN/dS values and fi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105384/ https://www.ncbi.nlm.nih.gov/pubmed/32223898 http://dx.doi.org/10.7554/eLife.48714 |