Cargando…

Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios

The distribution of fitness effects (DFE) defines how new mutations spread through an evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method to detect selection in somatic cells. However the link, in somatic evolution, between dN/dS values and fi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Williams, Marc J, Zapata, Luis, Werner, Benjamin, Barnes, Chris P, Sottoriva, Andrea, Graham, Trevor A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105384/ https://www.ncbi.nlm.nih.gov/pubmed/32223898 http://dx.doi.org/10.7554/eLife.48714

Ejemplares similares

The Population Genetics of dN/dS
por: Kryazhimskiy, Sergey, et al.
Publicado: (2008)

Why Time Matters: Codon Evolution and the Temporal Dynamics of dN/dS
por: Mugal, Carina F., et al.
Publicado: (2014)

The Influence of Selection for Protein Stability on dN/dS Estimations
por: Dasmeh, Pouria, et al.
Publicado: (2014)

The Impact of Recombination on dN/dS within Recently Emerged Bacterial Clones
por: Castillo-Ramírez, Santiago, et al.
Publicado: (2011)

Mutational Signatures Are Critical for Proper Estimation of Purifying Selection Pressures in Cancer Somatic Mutation Data When Using the dN/dS Metric
por: Van den Eynden, Jimmy, et al.
Publicado: (2017)

Slow but not low: genomic comparisons reveal slower evolutionary rate and higher dN/dS in conifers compared to angiosperms
por: Buschiazzo, Emmanuel, et al.
Publicado: (2012)

Identification of neutral tumor evolution across cancer types
por: Williams, Marc J, et al.
Publicado: (2016)

Absolute determination of D_s branching ratios and f_{D_s} extraction at a neutrino factory
por: De Lellis, G, et al.
Publicado: (2001)

Absolute determination of $D_s$ branching ratios and $f_{D_s}$ extraction at a neutrino factory
por: De Lellis, G., et al.
Publicado: (2001)

dN/dEta measurement at different multiplicities in ALICE
por: Liu, Xiaoyu
Publicado: (2016)

Observation of a resonant structure near the $D_s^+ D_s^-$ threshold in the $B^+\to D_s^+ D_s^- K^+$ decay
por: Aaij, Roel, et al.
Publicado: (2022)

Study of the measurement of the ratio $\mathcal R(D_s^*)$ at LHCb
por: Paolucci, L
Publicado: (2022)

Measurement of the $\bar{B}_s^0\to D_s^-D_s^+$ and $\bar{B}_s^0\to D^-D_s^+$ effective lifetimes
por: Aaij, R., et al.
Publicado: (2013)

Observation of neutrino induced diffractive $D_s^{*+}$ production and subsequent decay $D_s^{*+} \to D_s^+ \to \tau^+ \to \mu^+$
por: Annis, P, et al.
Publicado: (1998)

Double scaling limits and catastrophes of the zero-dimensional O(N) vector sigma model: D$_{4}$, D$_{5}$, E$_{6}$, E$_{7}$ and X$_{9}$
por: Rühl, Werner
Publicado: (1994)

Analysis of the freeze-out parameters for RHIC, SPS and AGS based on ${{dE_{T}} \over {d\eta}} / {{dN_{ch}} \over {d\eta}}$ ratio measurement
por: Prorok, D
Publicado: (2002)

First observation of the $B^+ \rightarrow D_s^+ D_s^- K^+$ decay
por: Aaij, Roel, et al.
Publicado: (2022)

Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data
por: Chkhaidze, Ketevan, et al.
Publicado: (2019)

Catch my drift? Making sense of genomic intra-tumour heterogeneity()()
por: Sottoriva, Andrea, et al.
Publicado: (2017)

Update of the measurement of R_c . P_c-> D_s and R_b . P_b-> D_s using inclusive D_s -> \Phi\pi and D_s -> K^* K channels
por: DELPHI Collaboration
Publicado: (2018)

Detecting truly clonal alterations from multi-region profiling of tumours
por: Werner, Benjamin, et al.
Publicado: (2017)

Measurement of B_s lifetime using D_s - lepton and inclusive D_s samples
por: DELPHI Collaboration
Publicado: (2018)

Measurement of R_c \cdot P_c -> D_s and R_b \cdot P_b -> D_s using inclusive D_S -> \Phi\pi and D_s -> K^\ast K channels
por: Laktineh, I, et al.
Publicado: (1996)

$dS_2$ supergravity
por: Muhlmann, Beatrix
Publicado: (2023)

Surreptitious M. D’s.
Publicado: (1857)

CAIN: Conglomérat d'ABEL et d'Interactions Non-linéaires
por: Chen, P, et al.
Publicado: (1994)

$B0 \to Ds^{(*)}Ds^{(*)}$ and outlook of $B0 \to D^{(*)}D$ at LHCb
por: Belloli, Nicoletta
Publicado: (2016)

Measurement of the $D_s^+ - D_s^-$ production asymmetry in 7 TeV pp collisions
por: Aaij, R, et al.
Publicado: (2012)

Evolution of clonal populations approaching a fitness peak
por: Gordo, Isabel, et al.
Publicado: (2013)

Universalités et fractales: jeux d'enfant ou délits d'initié?
por: Sapoval, B
Publicado: (1997)

Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates
por: Werner, Benjamin, et al.
Publicado: (2018)

Inferring clonal evolution of tumors from single nucleotide somatic mutations
por: Jiao, Wei, et al.
Publicado: (2014)

Introducci©đn a la Uni©đn Europea : un an©Łlisis desde la econom©Ưa /
por: Munõz de Bustillo Llorente, Rafael
Publicado: (1997)

Leptonic decays of the $D_s$ meson
por: Heister, A., et al.
Publicado: (2002)

Amplitude analysis of $B^0 \rightarrow \overline{D}^0 D_s^+ \pi^-$ and $B^+ \rightarrow D^- D_s^+ \pi^+$ decays
por: Aaij, R., et al.
Publicado: (2022)

Leptonic decays of the $D_s$ meson
por: Wasserbaech, S R, et al.
Publicado: (1999)

Spectroscopy of the excited $D_s^+$ mesons
por: Debernardis, F
Publicado: (2022)

Spectroscopy of the excited $D_s$ mesons
por: Debernardis, Francesco
Publicado: (2022)

The 4 D’s of Pellagra and Progress
por: Williams, Adrian C, et al.
Publicado: (2020)

Y. M. D’s Soliloquy
por: Merryman,
Publicado: (1886)

Cannot write session to /tmp/vufind_sessions/sess_c4ha2p7i7m6dkrrot9vttepffm