Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway

Hepatocellular carcinoma (HCC), a hepatic malignancy, has a poor prognosis and contributes to cancer-related death worldwide. Cellular senescence is an anticancer therapeutic strategy that causes irreversible cell cycle arrest and enables immune-mediated clearance of cancer cells. Atorvastatin, an H...

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Detalles Bibliográficos
Autores principales: Wang, Sin-Ting, Huang, Shi-Wei, Liu, Kuang-Ting, Lee, Teng-Yu, Shieh, Jeng-Jer, Wu, Chun-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105491/
https://www.ncbi.nlm.nih.gov/pubmed/32257389
http://dx.doi.org/10.1038/s41420-020-0252-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105491/
https://www.ncbi.nlm.nih.gov/pubmed/32257389
http://dx.doi.org/10.1038/s41420-020-0252-9

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