Cargando…

A lipophilic cation protects crops against fungal pathogens by multiple modes of action

The emerging resistance of crop pathogens to fungicides poses a challenge to food security and compels discovery of new antifungal compounds. Here, we show that mono-alkyl lipophilic cations (MALCs) inhibit oxidative phosphorylation by affecting NADH oxidation in the plant pathogens Zymoseptoria tri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Steinberg, Gero, Schuster, Martin, Gurr, Sarah J., Schrader, Tina A., Schrader, Michael, Wood, Mark, Early, Andy, Kilaru, Sreedhar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105494/ https://www.ncbi.nlm.nih.gov/pubmed/32231209 http://dx.doi.org/10.1038/s41467-020-14949-y

Ejemplares similares

Conditional promoters to investigate gene function during wheat infection by Zymoseptoria tritici
por: Fantozzi, Elena, et al.
Publicado: (2021)

Multi-site fungicides suppress banana Panama disease, caused by Fusarium oxysporum f. sp. cubense Tropical Race 4
por: Cannon, Stuart, et al.
Publicado: (2022)

Asynchronous development of Zymoseptoria tritici infection in wheat
por: Fantozzi, Elena, et al.
Publicado: (2021)

Myosin-5, kinesin-1 and myosin-17 cooperate in secretion of fungal chitin synthase
por: Schuster, Martin, et al.
Publicado: (2012)

Motor-driven motility of fungal nuclear pores organizes chromosomes and fosters nucleocytoplasmic transport
por: Steinberg, Gero, et al.
Publicado: (2012)

Long-distance endosome trafficking drives fungal effector production during plant infection
por: Bielska, Ewa, et al.
Publicado: (2014)

Peroxisomes, lipid droplets, and endoplasmic reticulum “hitchhike” on motile early endosomes
por: Guimaraes, Sofia C., et al.
Publicado: (2015)

Woronin body-based sealing of septal pores
por: Steinberg, Gero, et al.
Publicado: (2017)

Zymoseptoria tritici white-collar complex integrates light, temperature and plant cues to initiate dimorphism and pathogenesis
por: Kilaru, Sreedhar, et al.
Publicado: (2022)

Kinesin-3 and dynein cooperate in long-range retrograde endosome motility along a nonuniform microtubule array
por: Schuster, Martin, et al.
Publicado: (2011)

ATP prevents Woronin bodies from sealing septal pores in unwounded cells of the fungus Zymoseptoria tritici
por: Steinberg, Gero, et al.
Publicado: (2017)

Active diffusion and microtubule-based transport oppose myosin forces to position organelles in cells
por: Lin, Congping, et al.
Publicado: (2016)

Fluorescent markers of various organelles in the wheat pathogen Zymoseptoria tritici
por: Kilaru, S., et al.
Publicado: (2017)

Delocalized lipophilic cations as a new therapeutic approach in cancer
por: Ribeiro, A Barbosa, et al.
Publicado: (2010)

Boron-containing delocalised lipophilic cations for the selective targeting of cancer cells
por: Gianpiero, Calabrese, et al.
Publicado: (2016)

Lipophilic Cations Rescue the Growth of Yeast under the Conditions of Glycolysis Overflow
por: Sokolov, Svyatoslav S., et al.
Publicado: (2020)

A gene locus for targeted ectopic gene integration in Zymoseptoria tritici()
por: Kilaru, S., et al.
Publicado: (2015)

Identification and Mode of Action of a Plant Natural Product Targeting Human Fungal Pathogens
por: Dorsaz, Stéphane, et al.
Publicado: (2017)

Economic and physical determinants of the global distributions of crop pests and pathogens
por: Bebber, Daniel P, et al.
Publicado: (2014)

Fungi, fungicide discovery and global food security
por: Steinberg, Gero, et al.
Publicado: (2020)

The In Vitro Antitumour Activity of Novel, Mitochondrial-Interactive, Gold-Based Lipophilic Cations
por: Mahepal, Sherika, et al.
Publicado: (2008)

Correction: Boron-containing delocalised lipophilic cations for the selective targeting of cancer cells
por: Calabrese, Gianpiero, et al.
Publicado: (2017)

Self-Assembly of Functionalized Lipophilic Guanosines into Cation-Free Stacked Guanine-Quartets
por: Campitiello, Marilena, et al.
Publicado: (2021)

Molecular Diagnostics and Pathogenesis of Fungal Pathogens on Bast Fiber Crops
por: Cheng, Yi, et al.
Publicado: (2020)

Ocean Acidification Has Multiple Modes of Action on Bivalve Larvae
por: Waldbusser, George G., et al.
Publicado: (2015)

Effect of Relative Arrangement of Cationic and Lipophilic Moieties on Hemolytic and Antibacterial Activities of PEGylated Polyacrylates
por: Punia, Ashish, et al.
Publicado: (2015)

Phosphopantetheinyl transferase (Ppt)-mediated biosynthesis of lysine, but not siderophores or DHN melanin, is required for virulence of Zymoseptoria tritici on wheat
por: Derbyshire, Mark C., et al.
Publicado: (2018)

Author Correction: Phosphopantetheinyl transferase (Ppt)-mediated biosynthesis of lysine, but not siderophores or DHN melanin, is required for virulence of Zymoseptoria tritici on wheat
por: Derbyshire, Mark C., et al.
Publicado: (2019)

Measurement of virulence in Zymoseptoria tritici through low inoculum-density assays
por: Fones, Helen N., et al.
Publicado: (2015)

Special Issue “Interplay between Fungal Pathogens and Harvested Crops and Fruits”
por: Prusky, Dov B., et al.
Publicado: (2021)

Lipophilic Triphenylphosphonium Cations Inhibit Mitochondrial Electron Transport Chain and Induce Mitochondrial Proton Leak
por: Trnka, Jan, et al.
Publicado: (2015)

Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker
por: Prag, Hiran A., et al.
Publicado: (2020)

Conjugation of Natural Triterpenic Acids with Delocalized Lipophilic Cations: Selective Targeting Cancer Cell Mitochondria
por: Spivak, Anna Yu., et al.
Publicado: (2021)

Understanding Functional Redundancy and Promiscuity of Multidrug Transporters in E. coli under Lipophilic Cation Stress
por: Radi, Mohammad S., et al.
Publicado: (2022)

Cytoplasmic Fungal Lipases Release Fungicides from Ultra-Deformable Vesicular Drug Carriers
por: Steinberg, Gero
Publicado: (2012)

Lipophilic Allergens, Different Modes of Allergen-Lipid Interaction and Their Impact on Asthma and Allergy
por: Jappe, Uta, et al.
Publicado: (2019)

Spatial dynamics and control of a crop pathogen with mixed-mode transmission
por: McQuaid, Christopher Finn, et al.
Publicado: (2017)

Neuropsychiatric Consequences of Lipophilic Beta-Blockers
por: Cojocariu, Sabina Alexandra, et al.
Publicado: (2021)

Fracture of Thin-Walled Polyoxymethylene Bulk Specimens in Modes I and III
por: Schrader, Peer, et al.
Publicado: (2020)

Fluorescent markers of the microtubule cytoskeleton in Zymoseptoria tritici
por: Schuster, M., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_u1h0bhfht1i1rlhbb3tjh2aa1r