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Computational Design of High-Affinity Epitope Scaffolds by Backbone Grafting of a Linear Epitope
Computational grafting of functional motifs onto scaffold proteins is a promising way to engineer novel proteins with pre-specified functionalities. Typically, protein grafting involves the transplantation of protein side chains from a functional motif onto structurally homologous regions of scaffol...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105911/ https://www.ncbi.nlm.nih.gov/pubmed/22061265 http://dx.doi.org/10.1016/j.jmb.2011.10.003 |