The design and development of covalent protein-protein interaction inhibitors for cancer treatment

Protein-protein interactions (PPIs) are central to a variety of biological processes, and their dysfunction is implicated in the pathogenesis of a range of human diseases, including cancer. Hence, the inhibition of PPIs has attracted significant attention in drug discovery. Covalent inhibitors have...

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Detalles Bibliográficos
Autores principales: Cheng, Sha-Sha, Yang, Guan-Jun, Wang, Wanhe, Leung, Chung-Hang, Ma, Dik-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106679/
https://www.ncbi.nlm.nih.gov/pubmed/32228680
http://dx.doi.org/10.1186/s13045-020-00850-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106679/
https://www.ncbi.nlm.nih.gov/pubmed/32228680
http://dx.doi.org/10.1186/s13045-020-00850-0

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