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Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction
BACKGROUND: Base-excision repair (BER) is a central DNA repair mechanism responsible for the maintenance of genome integrity. Accordingly, BER defects have been implicated in cancer, presumably by precipitating cellular transformation through an increase in the occurrence of mutations. Hence, tight...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106853/ https://www.ncbi.nlm.nih.gov/pubmed/32228693 http://dx.doi.org/10.1186/s12915-020-00771-x |