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Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction

BACKGROUND: Base-excision repair (BER) is a central DNA repair mechanism responsible for the maintenance of genome integrity. Accordingly, BER defects have been implicated in cancer, presumably by precipitating cellular transformation through an increase in the occurrence of mutations. Hence, tight...

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Detalles Bibliográficos
Autores principales:	Clementi, Elena, Inglin, Larissa, Beebe, Erin, Gsell, Corina, Garajova, Zuzana, Markkanen, Enni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106853/ https://www.ncbi.nlm.nih.gov/pubmed/32228693 http://dx.doi.org/10.1186/s12915-020-00771-x

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