RNF8 promotes efficient DSB repair by inhibiting the pro‐apoptotic activity of p53 through regulating the function of Tip60

OBJECTIVES: RING finger protein 8 (RNF8) is an E3 ligase that plays an essential role in DSB repair. p53 is a well‐established tumour suppressor and cellular gatekeeper of genome stability. This study aimed at investigating the functional correlations between RNF8 and p53 in DSB damage repair. MATER...

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Detalles Bibliográficos
Autores principales: Chen, Hongyu, Shan, Jin, Liu, Jialing, Feng, Yunpeng, Ke, Yueshuang, Qi, Wenjing, Liu, Wenguang, Zeng, Xianlu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106964/
https://www.ncbi.nlm.nih.gov/pubmed/32031738
http://dx.doi.org/10.1111/cpr.12780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106964/
https://www.ncbi.nlm.nih.gov/pubmed/32031738
http://dx.doi.org/10.1111/cpr.12780

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