Cargando…

HJC0152 suppresses human non–small‐cell lung cancer by inhibiting STAT3 and modulating metabolism

OBJECTIVES: Signal transducer and activator of transcription 3 (STAT3) is constitutively activated and overexpressed in many cancers, including non–small‐cell lung cancer (NSCLC). We recently developed HJC0152 as an orally active STAT3 inhibitor. This study focused on investigating HJC0152's ef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Lu, Li, Hang, Wu, Xin, Rao, Jun, Zhou, Jia, Fan, Saijun, Shen, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106968/ https://www.ncbi.nlm.nih.gov/pubmed/32022328 http://dx.doi.org/10.1111/cpr.12777

Ejemplares similares

HJC0152, a novel STAT3 inhibitor with promising anti-tumor effect in gastric cancer
por: Jiang, Xiaoxia, et al.
Publicado: (2018)

Calculation method of HJC constitutive model parameters of natural joint angle slate
por: Wan, Antong, et al.
Publicado: (2023)

Cyanobactericidal Effect of Streptomyces sp. HJC-D1 on Microcystis auruginosa
por: Kong, Yun, et al.
Publicado: (2013)

Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice
por: Shekhar, Tanmay M., et al.
Publicado: (2019)

EHMTI-0152. Epidemiology of primary headaches among adolescents in republic of Croatia
por: Sedlic, M, et al.
Publicado: (2014)

PA01.52. Clinical observation of Dietary Influence in patients of pre-diabetes
por: Choudhary, Umesh, et al.
Publicado: (2012)

Phosphorylation of the Archaeal Holliday Junction Resolvase Hjc Inhibits Its Catalytic Activity and Facilitates DNA Repair in Sulfolobus islandicus REY15A
por: Huang, Qihong, et al.
Publicado: (2019)

Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152
por: Tchoghandjian, A, et al.
Publicado: (2016)

P01.52. Comparative study of two bioassays with stressed duckweed and yeast treated with homeopathic preparations
por: Jäger, T, et al.
Publicado: (2012)

Modifications of the HJC (Holmquist–Johnson–Cook) Model for an Improved Numerical Simulation of Roller Compacted Concrete (RCC) Structures Subjected to Impact Loadings
por: Wang, Chao, et al.
Publicado: (2020)

Concerted Suppression of STAT3 and GSK3β Is Involved in Growth Inhibition of Non-Small Cell Lung Cancer by Xanthatin
por: Tao, Li, et al.
Publicado: (2013)

Draft Nuclear Genome, Complete Chloroplast Genome, and Complete Mitochondrial Genome for the Biofuel/Bioproduct Feedstock Species Scenedesmus obliquus Strain DOE0152z
por: Starkenburg, S. R., et al.
Publicado: (2017)

Dynamin 3 Inhibits the Proliferation of Non-small-Cell Lung Cancer Cells by Suppressing c-MET–GBR2–STAT3 Complex Formation
por: Lu, Qiang, et al.
Publicado: (2021)

Annotation of a hypothetical protein coding gene PAS_chr2-2_0152 containing Lysine Methyl transferase SMYD domain from Komagataella phaffii GS115
por: Gogoi, Ridip Kumar, et al.
Publicado: (2019)

hsa-miR-212 modulates the radiosensitivity of glioma cells by targeting BRCA1
por: He, Xin, et al.
Publicado: (2018)

MiR-124 Suppresses Growth of Human Colorectal Cancer by Inhibiting STAT3
por: Zhang, Jufeng, et al.
Publicado: (2013)

TDP-43 upregulates lipid metabolism modulator ABHD2 to suppress apoptosis in hepatocellular carcinoma
por: Liu, Bo-wen, et al.
Publicado: (2022)

CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells
por: Li, Hang, et al.
Publicado: (2020)

Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling
por: Jia, Lifeng, et al.
Publicado: (2016)

Tetrandrine, an agonist of aryl hydrocarbon receptor, reciprocally modulates the activities of STAT3 and STAT5 to suppress Th17 cell differentiation
por: Yuan, Xusheng, et al.
Publicado: (2017)

Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway
por: Malemud, Charles J.
Publicado: (2010)

Maternal diabetes-mediated RORA suppression in mice contributes to autism-like offspring through inhibition of aromatase
por: Yu, Hong, et al.
Publicado: (2022)

Tumor growth suppression by inhibiting both autophagy and STAT3 signaling in HNSCC
por: Fan, Teng-Fei, et al.
Publicado: (2015)

Sex Differences of Radiation Damage in High-Fat-Diet-Fed Mice and the Regulatory Effect of Melatonin
por: Ren, Jingming, et al.
Publicado: (2022)

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
por: Lin, Li, et al.
Publicado: (2010)

STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis
por: Yanagimura, Naohiro, et al.
Publicado: (2022)

Interaction between leucine and phosphodiesterase 5 inhibition in modulating insulin sensitivity and lipid metabolism
por: Fu, Lizhi, et al.
Publicado: (2015)

Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signalling pathway
por: Fang, Kai, et al.
Publicado: (2021)

Novel direct AMPK activator suppresses non-small cell lung cancer through inhibition of lipid metabolism
por: Chen, Xi, et al.
Publicado: (2017)

Dual Inhibition of BRAF-MAPK and STAT3 Signaling Pathways in Resveratrol-Suppressed Anaplastic Thyroid Cancer Cells with BRAF Mutations
por: Lu, Meng-Di, et al.
Publicado: (2022)

MLKL inhibits intestinal tumorigenesis by suppressing STAT3 signaling pathway
por: Zhao, Qun, et al.
Publicado: (2021)

STAT1:DNA sequence-dependent binding modulation by phosphorylation, protein:protein interactions and small-molecule inhibition
por: Bonham, Andrew J., et al.
Publicado: (2013)

Shikonin Inhibits Tumor Growth of ESCC by suppressing PKM2 mediated Aerobic Glycolysis and STAT3 Phosphorylation
por: Zhang, Qiqi, et al.
Publicado: (2021)

Targeting STAT3 by a small molecule suppresses pancreatic cancer progression
por: Chen, Huang, et al.
Publicado: (2021)

Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells
por: Yang, Yang, et al.
Publicado: (2014)

Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway
por: Cummins, Claire B., et al.
Publicado: (2018)

Complement factor H inhibits endothelial cell migration through suppression of STAT3 signaling
por: Li, Jiang, et al.
Publicado: (2023)

Inhibition of STAT3 signaling as critical molecular event in HUC-MSCs suppressed Glioblastoma Cells
por: Wang, Mingming, et al.
Publicado: (2023)

Inhibition of STAT3 signaling as critical molecular event in resveratrol-suppressed ovarian cancer cells
por: Zhong, Li-Xia, et al.
Publicado: (2015)

Peiminine inhibits colorectal cancer cell proliferation by inducing apoptosis and autophagy and modulating key metabolic pathways
por: Zheng, Zhi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_jns197l3a6fv2lkmolf8h33g8g