A heterodimer of evolved designer-recombinases precisely excises a human genomic DNA locus

Site-specific recombinases (SSRs) such as the Cre/loxP system are useful genome engineering tools that can be repurposed by altering their DNA-binding specificity. However, SSRs that delete a natural sequence from the human genome have not been reported thus far. Here, we describe the generation of...

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Detalles Bibliográficos
Autores principales: Lansing, Felix, Paszkowski-Rogacz, Maciej, Schmitt, Lukas Theo, Schneider, Paul Martin, Rojo Romanos, Teresa, Sonntag, Jan, Buchholz, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107906/
https://www.ncbi.nlm.nih.gov/pubmed/31745551
http://dx.doi.org/10.1093/nar/gkz1078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107906/
https://www.ncbi.nlm.nih.gov/pubmed/31745551
http://dx.doi.org/10.1093/nar/gkz1078

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