A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment

The recruitment of substrates by the ser/thr protein phosphatase 2A (PP2A) is poorly understood, limiting our understanding of PP2A-regulated signaling. Recently, the first PP2A:B56 consensus binding motif, LxxIxE, was identified. However, most validated LxxIxE motifs bind PP2A:B56 with micromolar a...

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Detalles Bibliográficos
Autores principales: Wang, Xinru, Garvanska, Dimitriya H, Nasa, Isha, Ueki, Yumi, Zhang, Gang, Kettenbach, Arminja N, Peti, Wolfgang, Nilsson, Jakob, Page, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108865/
https://www.ncbi.nlm.nih.gov/pubmed/32195664
http://dx.doi.org/10.7554/eLife.55966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108865/
https://www.ncbi.nlm.nih.gov/pubmed/32195664
http://dx.doi.org/10.7554/eLife.55966

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