Cargando…
Identification of novel regulators of STAT3 activity
STAT3 mediates signalling downstream of cytokine and growth factor receptors where it acts as a transcription factor for its target genes, including oncogenes and cell survival regulating genes. STAT3 has been found to be persistently activated in many types of cancers, primarily through its tyrosin...
Autores principales: | Parri, Elina, Kuusanmäki, Heikki, van Adrichem, Arjan J., Kaustio, Meri, Wennerberg, Krister |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108870/ https://www.ncbi.nlm.nih.gov/pubmed/32231398 http://dx.doi.org/10.1371/journal.pone.0230819 |
Ejemplares similares
-
Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling
por: Kuusanmäki, Heikki, et al.
Publicado: (2017) -
Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP
por: van Adrichem, Arjan J., et al.
Publicado: (2015) -
Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors
por: Cichonska, Anna, et al.
Publicado: (2017) -
Standardized assays to monitor drug sensitivity in hematologic cancers
por: Ayuda-Durán, Pilar, et al.
Publicado: (2023) -
Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival
por: Elmadani, Manar, et al.
Publicado: (2019)