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Structure of an Endosomal Signaling GPCR–G Protein–β-arrestin Mega-Complex
Classically, G protein-coupled receptors (GPCRs) are thought to activate G protein from the plasma membrane and are subsequently desensitized by β-arrestin (βarr). However, some GPCRs continue to signal through G protein from internalized compartments, mediated by a GPCR–G protein–βarr ’megaplex’. N...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108872/ https://www.ncbi.nlm.nih.gov/pubmed/31740855 http://dx.doi.org/10.1038/s41594-019-0330-y |