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Structure of an Endosomal Signaling GPCR–G Protein–β-arrestin Mega-Complex

Classically, G protein-coupled receptors (GPCRs) are thought to activate G protein from the plasma membrane and are subsequently desensitized by β-arrestin (βarr). However, some GPCRs continue to signal through G protein from internalized compartments, mediated by a GPCR–G protein–βarr ’megaplex’. N...

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Detalles Bibliográficos
Autores principales: Nguyen, Anthony H., Thomsen, Alex R. B., Cahill, Thomas J., Huang, Rick, Huang, Li-Yin, Marcink, Tara, Clarke, Oliver B., Heissel, Søren, Masoudi, Ali, Ben-Hail, Danya, Samaan, Fadi, Dandey, Venkata P., Tan, Yong Zi, Hong, Chuan, Mahoney, Jacob P., Triest, Sarah, Little, John, Chen, Xin, Sunahara, Roger, Steyaert, Jan, Molina, Henrik, Yu, Zhiheng, des Georges, Amedee, Lefkowitz, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108872/
https://www.ncbi.nlm.nih.gov/pubmed/31740855
http://dx.doi.org/10.1038/s41594-019-0330-y