Polymorphic Aβ42 fibrils adopt similar secondary structure but differ in cross-strand side chain stacking interactions within the same β-sheet

Formation of polymorphic amyloid fibrils is a common feature in neurodegenerative diseases involving protein aggregation. In Alzheimer’s disease, different fibril structures may be associated with different clinical sub-types. Structural basis of fibril polymorphism is thus important for understandi...

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Detalles Bibliográficos
Autores principales: Wang, Hongsu, Duo, Lan, Hsu, Frederick, Xue, Christine, Lee, Yoon Kyung, Guo, Zhefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109039/
https://www.ncbi.nlm.nih.gov/pubmed/32235842
http://dx.doi.org/10.1038/s41598-020-62181-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109039/
https://www.ncbi.nlm.nih.gov/pubmed/32235842
http://dx.doi.org/10.1038/s41598-020-62181-x

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