The Extracellular Domain of Two-component System Sensor Kinase VanS from Streptomyces coelicolor Binds Vancomycin at a Newly Identified Binding Site

The glycopeptide antibiotic vancomycin has been widely used to treat infections of Gram-positive bacteria including Clostridium difficile and methicillin-resistant Staphylococcus aureus. However, since its introduction, high level vancomycin resistance has emerged. The genes responsible require the...

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Detalles Bibliográficos
Autores principales: Lockey, Christine, Edwards, Richard J., Roper, David I., Dixon, Ann M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109055/
https://www.ncbi.nlm.nih.gov/pubmed/32235931
http://dx.doi.org/10.1038/s41598-020-62557-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109055/
https://www.ncbi.nlm.nih.gov/pubmed/32235931
http://dx.doi.org/10.1038/s41598-020-62557-z

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