T-type calcium channel inhibition restores sensitivity to MAPK inhibitors in de-differentiated and adaptive melanoma cells

BACKGROUND: Drug resistance remains as one of the major challenges in melanoma therapy. It is well known that tumour cells undergo phenotypic switching during melanoma progression, increasing melanoma plasticity and resistance to mitogen-activated protein kinase inhibitors (MAPKi). METHODS: We inves...

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Detalles Bibliográficos
Autores principales: Granados, Karol, Hüser, Laura, Federico, Aniello, Sachindra, Sachindra, Wolff, Gretchen, Hielscher, Thomas, Novak, Daniel, Madrigal-Gamboa, Verónica, Sun, Qian, Vierthaler, Marlene, Larribère, Lionel, Umansky, Viktor, Utikal, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109069/
https://www.ncbi.nlm.nih.gov/pubmed/32063604
http://dx.doi.org/10.1038/s41416-020-0751-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109069/
https://www.ncbi.nlm.nih.gov/pubmed/32063604
http://dx.doi.org/10.1038/s41416-020-0751-8

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