TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages

Macrophages exist predominantly in two distinct states, G0 and a G1-like state that is accompanied by phosphorylation of SAMHD1 at T592. Here, we demonstrate that Toll-like receptor 4 (TLR4) activation can potently induce G0 arrest and SAMHD1 antiretroviral activity by an interferon (IFN)-independen...

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Detalles Bibliográficos
Autores principales: Mlcochova, Petra, Winstone, Helena, Zuliani-Alvarez, Lorena, Gupta, Ravindra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109521/
https://www.ncbi.nlm.nih.gov/pubmed/32209460
http://dx.doi.org/10.1016/j.celrep.2020.03.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109521/
https://www.ncbi.nlm.nih.gov/pubmed/32209460
http://dx.doi.org/10.1016/j.celrep.2020.03.008

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