Neuroprotection against Amyloid-β-Induced DNA Double-Strand Breaks Is Mediated by Multiple Retinoic Acid-Dependent Pathways

In this study, we have investigated the role of all-trans-retinoic acid (RA) as a neuroprotective agent against Aβ(1-42)-induced DNA double-strand breaks (DSBs) in neuronal SH-SY5Y and astrocytic DI TNC(1) cell lines and in murine brain tissues, by single-cell gel electrophoresis. We showed that RA...

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Detalles Bibliográficos
Autores principales: Colas, Julien, Chessel, Natacha, Ouared, Allaeddine, Gruz-Gibelli, Emmanuelle, Marin, Pascale, Herrmann, François R., Savioz, Armand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109576/
https://www.ncbi.nlm.nih.gov/pubmed/32256561
http://dx.doi.org/10.1155/2020/9369815

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