Alignment independent 3D-QSAR studies and molecular dynamics simulations for the identification of potent and selective S1P(1) receptor agonists

Sphingosine 1-phosphate type 1 (S1P(1)) receptors are expressed on lymphocytes and regulate immune cells trafficking. Sphingosine 1-phosphate and its analogues cause internalization and degradation of S1P(1) receptors, preventing the auto reactivity of immune cells in the target tissues. It has been...

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Detalles Bibliográficos
Autores principales: Alizadeh, Ali Akbar, Jafari, Behzad, Dastmalchi, Siavoush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110456/
https://www.ncbi.nlm.nih.gov/pubmed/31589999
http://dx.doi.org/10.1016/j.jmgm.2019.107459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110456/
https://www.ncbi.nlm.nih.gov/pubmed/31589999
http://dx.doi.org/10.1016/j.jmgm.2019.107459

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