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Alignment independent 3D-QSAR studies and molecular dynamics simulations for the identification of potent and selective S1P(1) receptor agonists
Sphingosine 1-phosphate type 1 (S1P(1)) receptors are expressed on lymphocytes and regulate immune cells trafficking. Sphingosine 1-phosphate and its analogues cause internalization and degradation of S1P(1) receptors, preventing the auto reactivity of immune cells in the target tissues. It has been...
Autores principales: | Alizadeh, Ali Akbar, Jafari, Behzad, Dastmalchi, Siavoush |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110456/ https://www.ncbi.nlm.nih.gov/pubmed/31589999 http://dx.doi.org/10.1016/j.jmgm.2019.107459 |
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