A Structural View of the Inactivation of the SARS Coronavirus Main Proteinase by Benzotriazole Esters

The main proteinase (M(pro)) of the severe acute respiratory syndrome (SARS) coronavirus is a principal target for the design of anticoronaviral compounds. Benzotriazole esters have been reported as potent nonpeptidic inhibitors of the enzyme, but their exact mechanism of action remains unclear. Her...

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Detalles Bibliográficos
Autores principales: Verschueren, Koen H.G., Pumpor, Ksenia, Anemüller, Stefan, Chen, Shuai, Mesters, Jeroen R., Hilgenfeld, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110992/
https://www.ncbi.nlm.nih.gov/pubmed/18559270
http://dx.doi.org/10.1016/j.chembiol.2008.04.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110992/
https://www.ncbi.nlm.nih.gov/pubmed/18559270
http://dx.doi.org/10.1016/j.chembiol.2008.04.011

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