Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential

Prohibitins (PHBs) are scaffold proteins that modulate many signaling pathways controlling cell survival, metabolism, and inflammation. Several drugs that target PHBs have been identified and evaluated for various clinical applications. Preclinical and clinical studies indicate that these PHB ligand...

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Autores principales: Thuaud, Frédéric, Ribeiro, Nigel, Nebigil, Canan G., Désaubry, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111013/
https://www.ncbi.nlm.nih.gov/pubmed/23521790
http://dx.doi.org/10.1016/j.chembiol.2013.02.006
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author Thuaud, Frédéric
Ribeiro, Nigel
Nebigil, Canan G.
Désaubry, Laurent
author_facet Thuaud, Frédéric
Ribeiro, Nigel
Nebigil, Canan G.
Désaubry, Laurent
author_sort Thuaud, Frédéric
collection PubMed
description Prohibitins (PHBs) are scaffold proteins that modulate many signaling pathways controlling cell survival, metabolism, and inflammation. Several drugs that target PHBs have been identified and evaluated for various clinical applications. Preclinical and clinical studies indicate that these PHB ligands may be useful in oncology, cardiology, and neurology, as well as against obesity. This review covers the physiological role of PHBs in health and diseases and current developments concerning PHB ligands.
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spelling pubmed-71110132020-04-02 Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential Thuaud, Frédéric Ribeiro, Nigel Nebigil, Canan G. Désaubry, Laurent Chem Biol Review Prohibitins (PHBs) are scaffold proteins that modulate many signaling pathways controlling cell survival, metabolism, and inflammation. Several drugs that target PHBs have been identified and evaluated for various clinical applications. Preclinical and clinical studies indicate that these PHB ligands may be useful in oncology, cardiology, and neurology, as well as against obesity. This review covers the physiological role of PHBs in health and diseases and current developments concerning PHB ligands. Elsevier Ltd. 2013-03-21 2013-03-21 /pmc/articles/PMC7111013/ /pubmed/23521790 http://dx.doi.org/10.1016/j.chembiol.2013.02.006 Text en Copyright © 2013 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Thuaud, Frédéric
Ribeiro, Nigel
Nebigil, Canan G.
Désaubry, Laurent
Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential
title Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential
title_full Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential
title_fullStr Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential
title_full_unstemmed Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential
title_short Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential
title_sort prohibitin ligands in cell death and survival: mode of action and therapeutic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111013/
https://www.ncbi.nlm.nih.gov/pubmed/23521790
http://dx.doi.org/10.1016/j.chembiol.2013.02.006
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