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IκB kinase ɛ (IKKɛ): A therapeutic target in inflammation and cancer

The innate immune system forms our first line of defense against invading pathogens and relies for a major part on the activation of two transcription factors, NF-κB and IRF3. Signaling pathways that activate these transcription factors are intertwined at the level of the canonical IκB kinases (IKKα...

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Detalles Bibliográficos
Autores principales: Verhelst, Kelly, Verstrepen, Lynn, Carpentier, Isabelle, Beyaert, Rudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111187/
https://www.ncbi.nlm.nih.gov/pubmed/23333767
http://dx.doi.org/10.1016/j.bcp.2013.01.007